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Exchange 2010 system requirements


http://technet.microsoft.com/en-us/library/dd346700.aspx

Important one here;

Multiple roles (combinations of Hub Transport, Client Access, and Mailbox server roles) 10 GB 10 GB plus 3-30 MB per mailbox (4 core server)

14 GB plus 3-30 MB per mailbox (8 core server)

18 GB plus 3-30 MB per mailbox (12 core server)

22 GB plus 3-30 MB per mailbox (16 core server)

30 GB plus 3-30 MB per mailbox (24 core server)

This is variable based on the user profile. For more details, see “Mailbox Server Role” later in this topic.

Also it is not supported on vSphere4, you require Update 1 for it to be supported from MS.

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